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Chiralic
Analysis
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UltraSep ES CHIR P
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(Pirkle
phases)
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In
UltraSep ES CHIR P (P means Pirkle) 3,5-DNB-D-a-phenylglycine
is coupled to the gel matrix via a spacer by an amide type bond (CHIRP,
D-Phegly). The 3,5-dinitrobenzoyl (DNB) residue acts as a p-electron
acceptor yielding good separation conditions for enantiomers with p-electrons.
For some separations the analogously constructed DNB-L-leucine phase with a
different selectivity is of advantage (CHIRP, L-Leu). This shows the peak
reversal of the (+) and (-) forms of 2,2,2-trifluoro-1-(9-anthryl)ethanol on
both packings (Application CHIRP). |
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UltraSep ES CHIR PMA
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(Polymer
phase)
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This
packing has a layer of polymeric methacrylic acid (PMA) on silica. It is
characterized by hydrophobic properties. Application CHIRPMA shows the separation
of 2,2,2-trifluoro-1-(9-anthryl)ethanol,
which is often used as "chiralic probe". As
a practical example the separation of
the optical isomers of the diuretic Cyclopenthiazid (Navidrex) is also
demonstrated..
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UltraSep ES RP Hypro Cu
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(Ligand
exchanger)
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UltraSep ES RP
Hypro Cu was developed especially for the chiralic separation of amino acids and
derivatized amino acids.
Underivatized
amino acids can be separated into their enantiomers by ligand exchange
chromatography. The special problem was besides, to determine the
N-acetyl compounds. All commercial ligand exchangers as far as checked were not
able to do this.
For this reason
SEPSERV developed a permanently loaded ligand exchange carrier on basis of
RP .
The combination of two chromatographical effects made it possible to achieve the
wanted separation (Application
CHIRLIG).
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Chiralic
Phases on the Basis of Carbohydrates
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Applications: |
Pharmaceutical
active compounds |
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Chiralic
compounds in foods, dyes and preservatives |
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Chiralic
catalysts and bioracemates |
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The
Eurocel phases are comparable with the corresponding Chiracel types. |
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Phase |
Polysaccharide |
Modification |
Application
Examples |
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Eurocel
01
corresp.
Chiralcel
OD |
Cellulose |
3,5-Dimethylphenyl-carbamate |
Alkaloides,
tropines, amines, beta blockers |
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Eurocel
02
corresp.
Chiralcel OB
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Cellulose
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Benzoate
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Small
aliphatic and aromatic compounds |
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Eurocel
03
corresp.
Chiralcel OJ
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Cellulose
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4-Methylbenzoate |
Arylmethyl
esters, Arylmethoxy esters |
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Eurocel
04
corresp.
Chiralcel OC
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Cellulose
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Phenylcarbamate
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Cyclopentenones
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The phases exhibit a very
good stability, a high capacity as well as a great flexibilty
relating to eluents. This is demonstrated by the example PROPRANOLOL. |
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Name us your separation
problem or order the list of applications via e-mail. |
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Particle sizes: 3, 5, 10,
and 20 µm. Column diameters:
2, 4, 4.6, 8, 16, and 20 mm. Column lengths: 125, 150, and 250 mm (analytical
columns) and 30, 120, and 250 mm (preparative columns). |
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Examples of
Separated Optical Antipodes |
Analyzed in Application
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Go to |
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D,L-Acetylmethionine
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CHIRLIG |
CHIRP |
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Cyclopenthiazid
(Navidrex) |
CHIRPMA |
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D,L-Methionine
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CHIRLIG |
CHIRPMA |
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(+,-)2,2,2-Trifluoro-1-(9-anthryl)ethanol |
CHIRP,
CHIRPMA |
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CHIRLIG |
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